Publicatons

Current evidence of whether proton pump inhibitor (PPI) reduces the risk of gastrointestinal bleeding (GIB) associated with oral anticoagulants (OACs) is limited. Propensity score-weighted cohort and case-crossover studies were conducted separately in England and Hong Kong between 2011.01.01 and 2019.12.31. In the cohort design, we compared the hazards of hospitalised GIB in OAC + PPI users with OAC only users in people with atrial fibrillation and found higher hazard of GIB in OAC + PPI users...

The dominant paradigm in clinical medicine, public health and global health has been to split clinical practice, research, education, training and funding into communicable versus non-communicable diseases. This dichotomy was borne out of the context of colonialism and increasingly, not least during the recent COVID-19 pandemic, evidence suggests that a much closer relationship between these 'disease siloes' would be beneficial, from risk factors to therapeutics. In this lecture, the synergies...

CONCLUSIONS: In overlapping HF, CKD and T2D, guideline-recommended care is suboptimal, with inequalities by age, sex, disease on first presentation and comorbidities. Quality improvement requires linked data collection, monitoring and action across diseases.

CONCLUSIONS: This research provides insights into how differences among countries in authorization and reimbursement mechanisms may impact the adoption and usage of medical devices, and may inform future policies on these processes.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the efficacy of weight loss interventions as adjunctive treatment for reducing atrial fibrillation burden.