Publications

Publicatons

Publications

Trajectory, healthcare utilisation and recovery in 3590 individuals with long covid: a 4-year prospective cohort analysis

CONCLUSIONS: In the largest long covid cohort from a single specialist post-COVID service to date, only one-third of individuals under follow-up achieved satisfactory recovery. Fatigue severity and COVID-19 vaccination at presentation, even after initial COVID-19 infection, was associated with long covid recovery. Ongoing service provision for this and other post-viral conditions is necessary to support care, progress treatment options and provide capacity for future pandemic preparedness....

Agreement of ethnicity reporting among patients with cancer with acute coronary syndrome: a national multiregistry analysis

Mohamed O Mohamed

CONCLUSION: Across four national datasets for patients with cancer with ACS, nearly half of patients had missing ethnicity in at least one dataset, which was associated with higher cardiac or cancer mortality. Inconsistency in ethnicity coding represents a missed opportunity to examine health inequalities in this high-risk and understudied population.

Correction: The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study

James P Sheppard

[This corrects the article DOI: 10.1371/journal.pmed.1004223.].

A systematic review and meta-analysis of the impact of vaccination on prevention of long COVID

Long COVID affects millions worldwide and its prevention is a critical public health strategy. While prior analyses show primary vaccination prevents long COVID in subsequent infections, the effect of booster vaccination on long COVID after Omicron infections is unclear. This systematic review identifies 31 observational studies, of which 11 are suitable for pairwise meta-analyses. The pooled odds ratio (OR) of long COVID in those vaccinated (any dose) versus unvaccinated is 0.77 (95% confidence...

A poly(3-methylthiophene)/borophene hybrid for tartaric acid detection

Tartaric acid (TA), a key organic acid in grapes and wine, is closely linked to taste quality and human health, making its accurate detection highly important. In this work, we report a borophene/poly(3-methylthiophene) (P3MTP) hybrid electrode fabricated via solvent-mediated exfoliation of borophene and electropolymerization of P3MTP on indium tin oxide (ITO) glass. The modified electrode was evaluated by cyclic voltammetry and interference studies, showing a wide linear detection range (5-300...

Cardiovascular disease in England: a delayed epidemic

Predicting hypotension, syncope, and fracture risk in patients indicated for antihypertensive treatment: the STRATIFY models

Constantinos Koshiaris

Antihypertensives are associated with increased risk of syncope, hypotension, and fractures, but the highest-risk individuals are unclear. This study aimed to develop and validate three models to predict these outcomes in patients with an indication for antihypertensive treatment. A cohort study was conducted using data from Clinical Practice Research Datalink (CPRD). Patients aged 40+ with systolic blood pressure 130-179 mmHg were included. Outcomes were first hypotension, syncope, or fracture...

Associations between falls and other serious adverse events and antihypertensive medication in individuals with dementia: An observational cohort study

Takeshi Fujiwara

CONCLUSIONS: Antihypertensive treatment was associated with increased risk of serious adverse events in individuals with and without dementia, however, the absolute risk of harm was more than double in individuals with dementia. These data suggest that clinicians, patients, and their carers should consider these risks before starting new antihypertensive medications, particularly in the context of dementia.

A Design Framework for Microintervention Software Technology in Digital Health: Critical Interpretive Synthesis

Dan Roland Persson

CONCLUSIONS: The resulting D-MIST framework, based on current state-of-the-art literature, describes the components of microintervention systems and how these contribute to a consolidated experience. Based hereon, we suggest opportunities for personalization of microintervention systems, discuss design guidelines, and the roles of actors in creating health narratives aiming to obtain better distal health outcomes.

2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias

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