Publicatons

Tartaric acid (TA), a key organic acid in grapes and wine, is closely linked to taste quality and human health, making its accurate detection highly important. In this work, we report a borophene/poly(3-methylthiophene) (P3MTP) hybrid electrode fabricated via solvent-mediated exfoliation of borophene and electropolymerization of P3MTP on indium tin oxide (ITO) glass. The modified electrode was evaluated by cyclic voltammetry and interference studies, showing a wide linear detection range (5-300...

Antihypertensives are associated with increased risk of syncope, hypotension, and fractures, but the highest-risk individuals are unclear. This study aimed to develop and validate three models to predict these outcomes in patients with an indication for antihypertensive treatment. A cohort study was conducted using data from Clinical Practice Research Datalink (CPRD). Patients aged 40+ with systolic blood pressure 130-179 mmHg were included. Outcomes were first hypotension, syncope, or fracture...

CONCLUSIONS: The resulting D-MIST framework, based on current state-of-the-art literature, describes the components of microintervention systems and how these contribute to a consolidated experience. Based hereon, we suggest opportunities for personalization of microintervention systems, discuss design guidelines, and the roles of actors in creating health narratives aiming to obtain better distal health outcomes.

No abstract

Comprehensively mapping all targets of a T cell receptor (TCR) is important for predicting pathogenic escape and off-target effects of TCR therapies. However, this mapping has been challenging due to lack of unbiased benchmarking datasets and computational methods sensitive to small-peptide mutations. To address this, we curated the benchmark for activation of T cells with cross-reactive avidity for epitopes (BATCAVE) database, encompassing near-complete single-amino-acid mutational assays,...