Publications

Publicatons

Publications

Variations in the Risk of New-Onset Diabetes Following COVID-19 Infection Across Body Mass Index, Deprivation, Ethnicity and Geographic Regions: Population-Based Cohort Study in 42 Million People in England

Sharmin Shabnam

CONCLUSIONS: In this cohort, COVID-19 was associated with a modest, short-term increase in T2D risk and showed no meaningful association with T1D. Established metabolic, demographic and socioeconomic factors-including age, BMI, deprivation and ethnicity-were more strongly associated with T2D incidence than COVID-19 exposure.

Potential interactions between SSRIs and DOACs: population-based cohort and case-crossover study

CONCLUSION: We found no evidence of increased risk of intracranial and gastrointestinal bleeding during concomitant use of DOAC+SSRI in the cohort analysis. However, the case-crossover analysis suggested some evidence of a higher risk of other bleeding when initiating SSRIs (but not non-SSRIs) while taking DOACs.

Manuscript Title: Sex differences in patients hospitalized for repair of intact abdominal aortic aneurysms in eleven high-income countries: A cross-sectional cohort study

CONCLUSIONS: Compared to males, females had lower AAA population-adjusted incidence of surgeries, higher mortality, higher readmission rates, and longer hospital LOS across 11 diverse high-income countries. However, the magnitude of the female-male differences were surprisingly variable. These findings raise important questions about whether these differences are manifestations of true clinical differences across countries or differences in how males and females are treated in each country. We...

Dyslipidaemia and cardiovascular risk - Key considerations in South Asians

Aneesha Chauhan

Cardiovascular disease remains the leading global cause of mortality. It disproportionately affects South Asians, who face an approximately two-fold higher risk of atherosclerotic cardiovascular disease (CVD), with a particularly pronounced excess risk of coronary heart disease and myocardial infarction, when compared to White Caucasians. Dyslipidaemia is a major modifiable CVD risk factor, with South Asians being predisposed to more atherogenic lipid profiles. Understanding cardiovascular risk...

WHF Roadmap for Integrated Care in People Living with - or at Risk of - Cardiovascular Disease and Multiple Long-Term Conditions

Laurence Sperling

Cardiovascular disease (CVD) commonly coexists with multiple long-term conditions (MLTC), including diabetes, chronic kidney disease, obesity, and mental health disorders. This clustering creates a syndemic burden associated with poorer outcomes, polypharmacy, high treatment burden, and rising healthcare costs. Fragmented, single-disease care models are ill-suited to address this complexity. The WHF roadmap for integrated care in people living with - or at risk of - CVD and MLTC provides a...

Considerations for epidemiological studies investigating emerging post-acute infection syndromes: Long Covid as a case study

Daniel Ayoubkhani

Epidemiological research studies into Long Covid, currently defined by prolonged symptoms after SARS-CoV-2 infection, have reported widely varying prevalence estimates. As well as rapidly evolving scientific knowledge of Long Covid, these differences are partly driven by substantial methodological heterogeneity between studies, including the outcome definition of Long Covid; duration of follow-up; study design, period and population; sampling frame; data source; and the statistical techniques...

Estimating real-world treatment effects in the presence of measurement error and sparse outcome data using propensity score methods

CONCLUSION: This study showed that PS methods proposed in the literature may not all perform well for individual datasets. The findings produced recommendations for using PS methods in the estimation of real-world treatment effect when the covariate measurement error and sparse outcome data are present.

Heart failure with reduced ejection fraction: A systematic review of clinical practice guidelines and recommendations

Heart failure with reduced ejection fraction (HFrEF) accounts for over half of heart failure cases and its management is directed by international clinical practice guidelines. To evaluate current recommendations, we conducted a systematic review of guidelines on the diagnosis and management of HFrEF in adults. MEDLINE and EMBASE were searched on 10 November 2024 for publications within the past decade, and websites of relevant medical societies were reviewed. Twelve guidelines were identified,...

Review of MASLD in Adults

Muhammad Shahzeb Khan

Setting research priorities for the use of digital technology in the self-management of heart health: the results of the James Lind Priority Setting Partnership

CONCLUSION: Future funding should be directed towards research questions identified by patients and healthcare professionals.

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